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Statistical analysis Statistical analysis was performed with the GraphPad Prism 8 software (GraphPad Software, San Diego, CA, United States)

(2) Mitochondrial dysfunction in DAAs and reactive astrocytes Impaired oxidative phosphorylation (OXPHOS) DAAs exhibit reduced mitochondrial respiratory chain activity, leading to decreased ATP production via OXPHOS

Finally, interactions between TfRs and hemeHPX provide a key to expanding our understanding of the regulation of the complex relationships between systemic heme and iron metabolism and their clinical relevance and importance

It is a pentadecapeptide, which means that it consists of 15 amino acids